Fluoroquinolone toxicity is the result of antibiotics that can cause extreme, whole-body effects that range which range from nausea, diarrhea vomiting, to depression and psychosis. This is also known as Floxing.
Patients who have suffered from adverse effects from a fluoroquinolone/quinolone antibiotic should avoid fluoroquinolones. The elderly, those over 65, suffering from kidney problems or who have received organ transplants should be given special consideration.
Fluoroquinolones are the major component of antibacterial quinolones. They contain the fluorine atom, and are effective against Gram negative and Gram positive bacteria.
Fluoroquinolones kill bacteria through blocking enzymes which normally break up DNA during the process of cell reproduction. These enzymes usually cut DNA’s doublehelix, pass another strand of DNA through the gap, and then fix the cut.
Quinolones can be able to attach to enzymes, which prevents them from fixing their cuts. Fluorine atoms were added to the quinolones’ structure in the 1980s. This enabled antibiotics to penetrate every tissue in the body, including the central nerve system. This also enhanced their efficacy against a wide variety of bacterial diseases.
Fluoroquinolones can prove useful in certain infections, some of them life-threatening, when other antibiotics are not sufficient to treat the problem.
But, they are also over-used in the same way as antibiotics are. There have been serious side effects related to them through the years, and many cautions from the FDA limit their use. Many label modifications have been required and certain fluoroquinolones carry warnings on the black box.
Which antibiotics can be called fluoroquinolones
These include Cipro (Cipro), Gemifloxacin(Factive) Levofloxacin/Levaquin Norfloxacin/Noroxin Cipro (Cipro), Cipro (Cipro), Cipro (Cipro), Cipro (Cipro), Cipro (Factive), Levofloxacin/Levaquin), Levofloxacin/Levaquin) Levofloxacin/Floxacin/Floxin (Floxin) and ofloxacin/Floxacin/Floxin (Floxin (Floxin), Cipro) Gemifloxacin/Floxin (Floxin) and ofloxacin/Floxacin/Floxin (Floxin) Aveloxacin) and ciprofloxacin).
What is Fluoroquinolone Toxicity Syndrome?
Signs + Symptoms
Fluoroquinolone medications have been associated with potential serious, long-term and permanently debilitating adverse effects, such as toxicity to the central nerve system, cardiovascular system, and musculoskeletal systems. Other signs of Ciprotoxicity include:
– Damage to mitochondrial DNA and mitochondrial dysfunction
– Brain Fog
– Peripheral Neuropathy
– Blurry Vision
– DNA Damage
– Gaba and Gut damage can trigger anxiety and depression.
– Muscle Atrophy
– Reflexes that are more sensitive
Ciprotoxicity signs include low back pain, tendonitis, tendon rupture and arthralgia. In the long run, fluoroquinolones can increase the risk of peripheral neuropathy by 47%..
Ciprofloxacin has been shown to block normal maintenance and transcription of mitochondrial DNA, by altering mtDNA topology. Tendinitis and tendon fractures could result from damage to the tenocyte mitochondria caused by the fluoroquinolone treatment. It can also lead to fatigue or inflammation.
For more information, click how to heal from floxing